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Mounjaro was approved by the FDA in 2022 as a GIP and GLP-1 receptor agonist for improving blood sugar control in adults with type 2 diabetes, and subsequent trials went on to evaluate its effects specifically on body weight in people with obesity or overweight
Patient's started on a lower dose and then built up gradually to reduce side effects
PRL acts on specific dopamine neurons in the hypothalamic arcuate nucleus and periventricular nucleus that increase dopamine secretion which tuberoinfundibular pathway inhibit prolactin release from the pituitary gland (61) ( Figure 2 )
No overall differences in safety or effectiveness for RYBELSUS have been observed between patients 65 years of age and older and younger adult patients
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